With an ex-Presidential candidate as its pitchman, more mentions on late-night talk shows than Joan Embry and the dubious honor of being the world’s top medical treatment for impotence, few drugs in history have been more in the public eye more than Viagra – or gotten more attention for affecting the public’s eyes. Since receiving FDA approval in March 1998, Viagra has been prescribed more than 22 million times in the U.S. alone and is available in 90 other countries, according to manufacturer Pfizer. Here’s what you need know about Viagra and your vision:
Along with its impact below the belt, Viagra (Sildenafil Citrate 100mg) is well-documented to cause retinal dysfunction lasting several hours after it is taken. Most commonly, it causes increased light sensitivity, blurring, and a bluish tint or haze to vision in many men who take the medication.
Some people believe much of the misinformation published by those who would have them pay ten times more for genuine drugs rather than the far cheaper generic versions. Well, here is why the vast difference exists. It’s no secret, nor is it difficult to understand. It’s simply economics versus opportunism (although sometimes justified).Much of the confusion and misconception exists because, understandably, many can’t see how the generic drug can be the same thing but be so cheap.
When the drug is first researched, found and developed, it takes a number of years and many, many millions (if not billions) of dollars in research, failure, more research, testing through multiple stages. Then come the trials, which have to satisfy the likes of the FDA (most countries have their own version of the FDA), which can, again, take years and more millions and even still fail for one reason or another.
Even someone who has been living under a rock for the last five or so years would be aware of the confusion, misconception and questions that exist regarding generic prescription drugs, especially the largest selling online, by far, Sildenafil Citrate and other drugs used for the treatment of erectile dysfunction.
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Who is most likely to get ocular side effects?
Sildenafil is available in three prescribed doses – 25, 50 and 100 mg pills. Side effects are usually dose-related, meaning the greater the dosage, the greater the risk. According to reports by Pfizer and subsequent studies, ocular side effects occur in:
About 50 percent of men taking 200 mg
About 11 percent taking 100 mg doses
About 3 percent of men taking doses of 25-50 mg
Nearly all men taking 600 to 800 mg.
Why does Sildenafil cause vision changes? However, the drug also has a milder inhibiting effect on PDE-6, an enzyme actively present in retinal photoreceptors. This causes an increase in the concentration of cyclicGMP, resulting in a depolarization of the rod cell – and increased light sensitivity and the infamous “blue vision.” Sildenafil is effective on erectile dysfunction because it inhibits phosphodiesterase 5 (PDE-5), an enzyme that enhances the effects of nitric oxide, which is released during sexual stimulation to relax the smooth muscle of the penis and facilitate blood inflow.